APPLIED MOLECULAR MICROBIOLOGY

With the course of Applied Molecular Microbiology, students will broaden and deepen the basic
knowledge in the biomolecular field captured with the first degree. The course explores the molecular
aspects of pathogenicity, virulence and antibiotic resistance of the major human pathogens, and their
clonal relationship. The new identification technologies and study of microorganisms are also addressed
(genomes, metagenomes, proteomes etc) as well as the basics of the interaction host parasite including
immunological aspects. From the application point of view, they are taken into consideration the vaccine
preparations (both traditional and recombinant) as well as some examples of microbial products
produced with advanced technologies. The students then, will possess an integrated understanding of
biological phenomena and advanced scientific training in morphological / functional level, chemical /
biochemical, cellular / molecular and evolutionary aspects of the microbial world.

Study of microrganisms involved in bio-medical and industrial applications.
Overview of taxonomy and identification of microrganisms. Host-parasite relationships. Molecular
mechanisms of pathogenicity.
Molecular biotechnology of microbial systems. Phylo-genomics: the benefit between phylogeny
reconstruction and genomic analyses.
Genetics, genomics, metagenomics, transcriptomics and application.
Screening for microbial Products: bacteria Enzymes, monoclonal and polyclonal antibodies, nucleic acids as
therapeutic agents.
Study of molecular mechanisms of antibiotic-resistance. Vaccines. Traditional and recombinant
technologies in industrial microbiology.

1. Deho' Galli - Biologia dei Microrganismi - Casa editrice EA
2. Brock – Biologia dei Microrganismi – vol. 2 Casa Editrice CEA
3. Perry JJ et al – Microbiologia vol 2 – Casa Editrice Zanichelli
4. https://onlinelibrary.wiley.com/doi/book/10.1002/9780470688618 (free for all students)
For consulation:
1. Glick et al – Molecular Biotechnology 3th ed. ASM
2. Brodgen KA et al – Virulence mechanisms of bacterial pathogens 3th ed ASM
3. Specific publications