The research concerns the identification of polymorphisms that can allow, from the genotypic analysis of an anonymous DNA sample, to obtain a profile for some relevant characters such as oculocutaneous pigmentation, predisposition to physical dimorphisms, height and weight, considered complex traits since these are phenotypic characteristics due to several genetic as well as environmental factors. Current use of DNA in the forensic context is based on comparing DNA profiles obtained from crime scene material with that of known potential suspects, however, a viable option to potentially avoid or retrospectively resolve cold cases is to predict phenotypic characteristics (EVCs, Externally Visible Characteristics) using informative molecular markers. As predictors of EVCs, applications can be useful to lead police investigations to specific groups of people, thereby reducing the number of potential suspects to be analyzed by conventional DNA profiling. Unfortunately, at the moment, the molecular genetics of individual specific EVCs remain unknown, with little hope for immediate forensic application. However, a number of EVCs, such as eye color, are the most understood and the main focus is on the development of models for the prediction of phenotypes based on the genotype as well as the characterization of the polymorphic sites involved in the determination of iris colour.