Biochemical and biomolecular approaches to degenerative diseases

Module Biomolecular approaches to degenerative diseases

This module aims to address the vast field of the most widespread degenerative disease, cancer, highlighting the role of concepts and topics studied in basic molecular biology. In other words, it will be highlighted how in cancer the dysregulation or destruction of processes and structures studied in molecular biology are the very basis of the pathological phenomenon. The student will then deepen concepts of molecular biology applied to this degenerative disease.

To provide a complete and wide-ranging introduction to the panorama of molecular knowledge and the state of research into the causes of cancer.

The course includes frontal lessons with the use of ppt slides, animation/video, exercises and seminars.

Should teaching be carried out in mixed mode or remotely, it may be necessary to introduce changes with respect to previous statements, in line with the programme planned.
 

    The nature of cancer - cellular aspects - epidemiological aspects - risk factors
    Tumor viruses
    Cellular Oncogenes
    Overview of intracellular signaling routes
    Tumor Suppressor Genes - pRB
    Cell cycle and its control
    Apoptosis - control by p53
    Immortalisation of cancer cells - role of telomeres
    Maintaining genome integrity

L. Pecorino Biologia molecolare del cancro Zanichelli 2010

R.A. Weinberg La Biologia del Cancro Zanichelli 2016